Establishment of axon regeneration regulatory network and the role of low intensity pulsed ultrasound in the network

Chunyang Liu, Yanhua Xu, Hong Yang, Jianhua Zhang
2019 Saudi Journal of Biological Sciences  
To establish an axon regeneration regulatory network for optimal selection, and explore the role of low intensity pulsed ultrasound in the network. The axon regeneration regulatory network involving axon regeneration-related proteins NGF, BDNF and PirB was constructed by using GO and KEGG. The maximum possible pathway acting on axon regeneration was screened by Bayesian network theory. The node of low - intensity pulsed ultrasound in NGF - involved axon regeneration network was complemented by
more » ... ombining literature methods. The NGF, BDNF and PirB-involved axonal regeneration regulatory pathway was successfully constructed. The low intensity pulsed ultrasound played a role in axon regeneration by acting on ERK1/2-CREB pathway and GSK-3β. NGF-TrKA-Rap1-ERK1/2-CREB-Bcl-2 was optimized as optimal pathway by Bayesian theory. The regulatory pathway of axon regeneration involving nerve growth related factors and low intensity pulsed ultrasound was initially established, which provided a theoretical basis for further study of axon regeneration, and also new ideas for action of low intensity pulsed ultrasound on axon regeneration regulatory pathway.
doi:10.1016/j.sjbs.2019.07.007 pmid:31889775 pmcid:PMC6923491 fatcat:t45jxiaenjbgvig4jzu5hszupq