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Amino acids fulfil a diverse range of roles in proteins, each utilising its chemical properties in different ways in different contexts to create required functions. For example, cysteines form disulphide or hydrogen bonds in different circumstances and charged amino acids do not always make use of their charge. The repertoire of amino acid functions and the frequency at which they occur in proteins remains understudied. Measuring large numbers of mutational consequences, which can elucidatedoi:10.15252/msb.202110305 pmid:34292650 pmcid:PMC8297461 fatcat:ucimjzbbcjatnexdeu6ceyqqbe