Interrogating the Functional Correlates of Collateralization in Patients with Intracranial Stenosis Using Multimodal Hemodynamic Imaging

B.A. Roach, M.J. Donahue, L.T. Davis, C.C. Faraco, D. Arteaga, S.-C. Chen, T.R. Ladner, A.O. Scott, M.K. Strother
2016 American Journal of Neuroradiology  
BACKGROUND AND PURPOSE: The importance of collateralization for maintaining adequate cerebral perfusion is increasingly recognized. However, measuring collateral flow noninvasively has proved elusive. The aim of this study was to assess correlations among baseline perfusion and arterial transit time artifacts, cerebrovascular reactivity, and the presence of collateral vessels on digital subtraction angiography. MATERIALS AND METHODS: The relationship between the presence of collateral vessels
more » ... arterial spin-labeling MR imaging and DSA was compared with blood oxygen level-dependent MR imaging measures of hypercapnic cerebrovascular reactivity in patients with symptomatic intracranial stenosis (n ϭ 18). DSA maps were reviewed by a neuroradiologist and assigned the following scores: 1, collaterals to the periphery of the ischemic site; 2, complete irrigation of the ischemic bed via collateral flow; and 3, normal antegrade flow. Arterial spin-labeling maps were scored according to the following: 0, low signal; 1, moderate signal with arterial transit artifacts; 2, high signal with arterial transit artifacts; and 3, normal signal.
doi:10.3174/ajnr.a4758 pmid:27056428 pmcid:PMC4907824 fatcat:dl66hciusjegrnpyrm2srszsqa