Objective: The purpose of this research work is to assess the relationship of the diseases of vitiligo and dry eye with objective features. Methodology: This research work carried out on 20 patients of vitiligo and 21 patients suffering from not complicated refractory issues. All these patients had to undergo complete examination through ophthalmology including Fluorescein Breakup Time, Corneal Fluorescein Staining and Schirmer Test-1. The evaluation of the status of the dry eye carried out by

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... he average of the Ocular Surface Disease Index. Results: Both of the groups were same about the age of the patients and the distribution of gender. The group of the vitiligo was present with the high scores of Ocular Surface Disease Index (24.8 ± 13.88 Vs 12.68 ± 3.38), short FBU (5.78 ± 2.88 Vs 7.78 ± 2.18 and very high Corneal Fluorescein Staining positivity 16.0/28.0 versus 3.0/29.0 as compared to the group of healthy controls. The patients of both groups were same regarding the Meibomian Gland Dysfunction and results of the Schirmer test. Total 44.68% patients of vitiligo were present with the peri-ocular involvement. The examination in the patients of vitiligo discovered that there were short Fluorescein Breakup Time and Schirmer test in the patients present with the peri-ocular involvement; there were same scores of Ocular Surface Disease Index and the status of the Meibomian Gland Dysfunction. Conclusion: This research work proposes a possible relationship of the diseases dry eye and vitiligo. The diagnostic tools for the disease of dry eye are in better association with one another. The questionnaire of Ocular Surface Disease Index seems empirical for both diagnostic reasons as well as follow-ups. KEY WORDS: Meibomian Gland Dysfunction, Ocular Surface Disease Index, Fluorescein Breakup Time, Schirmer, Corneal, Vitiligo, Dysfunction.