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Increased urinary angiotensin converting enzyme 2 and neprilysin in patients with type 2 diabetes
2018
AJP - Renal Physiology
Angiotensin converting enzyme 2 (ACE2) and neprilysin (NEP) are metalloproteases that are highly expressed in the renal proximal tubules. ACE2 and NEP generate renoprotective angiotensin (1-7) from angiotensin II and angiotensin I, respectively, and therefore could have a major role in chronic kidney disease (CKD). Recent data demonstrated increased urinary ACE2 in patients with diabetes with CKD and kidney transplants. We tested the hypothesis that urinary ACE2, NEP, and a disintegrin and
doi:10.1152/ajprenal.00565.2017
pmid:29561187
pmcid:PMC6139527
fatcat:dq5w4vybl5dcpeqi2cjva4v2la