A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Modelling and Simulation of the Hydrodynamics and Mixing Profiles in the Human Proximal Colon Using Discrete Multiphysics
[post]
2020
unpublished
The proximal part of the colon offers opportunities to prolong the absorption window following oral administration of a drug. In this work, we used computer simulations to understand how the hydrodynamics in the proximal colon might affect the release from dosage forms designed to target the colon. For this purpose, we developed and compared three different models: a completely-filled colon, a partially-filled colon and a partially-filled colon with a gaseous phase present (gas-liquid
doi:10.20944/preprints202004.0198.v1
fatcat:u5thfy776fha7epkbgdlckssiq