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FISIK: Framework for the Inference of in Situ Interaction Kinetics from single-molecule imaging data
[article]
2019
bioRxiv
pre-print
Recent experimental and computational developments have been pushing the limits of live-cell single-molecule imaging, enabling the monitoring of inter-molecular interactions in their native environment with high spatiotemporal resolution. However, interactions are captured only for the labeled subset of molecules, which tends to be a small fraction. As a result, it has remained a challenge to calculate molecular interaction kinetics, in particular association rates, from single-molecule
doi:10.1101/530063
fatcat:blltkbsrfzbg3hjwp32tyxgl6i