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Prospective grading of neoplastic change in rat esophagus epithelium using angle-resolved low-coherence interferometry
2005
Journal of Biomedical Optics
Angle-resolved low-coherence interferometry ͑a/LCI͒ is used to obtain quantitative, depth-resolved nuclear morphology measurements. We compare the average diameter and texture of cell nuclei in rat esophagus epithelial tissue to grading criteria established in a previous a/LCI study to prospectively grade neoplastic progression. We exploit the depth resolution of a/LCI to exclusively examine the basal layer of the epithelium, approximately 50 to 100 m beneath the tissue surface, without the
doi:10.1117/1.2102767
pmid:16292952
fatcat:qa3bpsdqozfljgefgwt36j6p6m