Contributions MK is the guarantor of this review. KM, MK, and HK drafted the manuscript. All authors contributed to the development of the selection criteria, the risk of bias assessment strategy, and data extraction criteria. HK developed the search strategy in cooperation with KM and MK. KM and MK provided statistical expertise. RB, TG, FL, PS, CFV, and MW provided expertise on alpha-1-antitrypsin deficiency. All authors read, provided feedback, and approved the final manuscript. Registration

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... The systematic review on patient-related outcome measures (PROM) for assessing quality of life (QoL) in patients with alpha-1-antitrypsin deficiency (AATD) was registered at PROSPERO (CRD 42021265360). Support The systematic review is part of a larger project. The project is financially supported by CSL Behring GmbH. The funder has no role in the design and conduct of the study. Acknowledgment We thank Brigitte Doß for the peer review of the search strategy for the systematic review and Monika Schöll for the linguistic revision of the systematic review protocol.