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Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"
2008
Blood
We have identified at least 2 highly promiscuous major histocompatibility complex class II T-cell epitopes in the Fc fragment of IgG that are capable of specifically activating CD4 ؉ CD25 Hi FoxP3 ؉ natural regulatory T cells (nT Regs ). Coincubation of these regulatory T-cell epitopes or "Tregitopes" and antigens with peripheral blood mononuclear cells led to a suppression of effector cytokine secretion, reduced proliferation of effector T cells, and caused an increase in cell surface markers
doi:10.1182/blood-2008-02-138073
pmid:18660382
pmcid:PMC2569179
fatcat:lkwgtvq3yjgkjldoswcakrczf4