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The mechanisms that govern organelle properties to suit the needs of a cell remain poorly defined. Lysosomes degrade cargo from various routes including endocytosis, phagocytosis and autophagy. For phagocytes, lysosomes are a kingpin organelle since they are essential to kill pathogens and process antigens. During phagocyte activation, lysosomes undergo a striking reorganization, changing from dozens of globular structures to a tubular network, in a process that requires thedoi:10.1101/260257 fatcat:ixsw7cz4lfhizpxr4syezl52eu