Impact of the 5008 monitor software update on total convective volume

Francisco Maduell, Néstor Rodríguez, Laura Sahdalá, Diego Coronel, Marta Arias Guillén, Raquel Ojeda, Manel Vera, Néstor Fontseré, Aleix Cases, Josep M Campistol
2014 Nefrología  
On-line haemodiafiltration (OL-HDF) is based on the controlled administration of large volumes of replacement ultrapure dialysate to the extracorporeal blood circuit of dialysis. It is currently the most effective technique for eliminating small and large uraemic toxins. Recent studies have observed a direct association between a decrease in mortality and the received convective volume. The latest Fresenius 5008 (5008 CorDiax) monitor software update enables the automation of the replacement
more » ... the replacement volume without requiring total protein and haematocrit values, with the aim of maximising convection. The study's objective was to evaluate the recent version of the 5008 monitor software, compared to the previous version, on the impact on total convective volume. We included 63 patients (44 males and 19 females), with a mean age of 65.2 ± 15 years, on OL-HDF. Each patient was analysed in 6 sessions; 3 with the 5008 monitor and 3 with the 5008 CorDiax monitor. The replacement volume, total convective volume and dialysis parameters were determined in each session. No significant differences were observed in blood, venous or transmembrane pressure, nor was there an increase in the number of alarms or coagulation of lines or dialysers. A significant increase of replacement fluid volume, from 27.2 to 31.2 L/session, was observed using the CorDiax software. Total convective volume increased from 29.5 to 33.3 L/session, representing an effective convective volume increase from 26 % to 29.6 % of total filtered blood. The 5008 dialysis monitor software update has meant a 13 % increase of total convective volume and a 3.5 % increase of total filtered blood.
doi:10.3265/Nefrologia.pre2014.Apr.12508 pmid:25036263 fatcat:xfig35g3gbfvpn3234r3otwszu