Synthesis of Cyclohexanones through a Catalytic Cationic Cyclization of Alkynols or Enynes [component]

A novel procedure for the synthesis of cyclohexanones from alkynol or enyne derivatives through a cationic cyclization has been developed. Key points to get the six-membered ring derivatives are the use of starting materials containing a terminal alkyne, the use of tetrafluoroboric acid as promoter of the cationic cyclization and the appropriate election of 1,1,1,3,3,3hexafluoropropan-2-ol (HFIP) as solvent. This strategy can be extended to the biomimetic cationic cyclization of several
more » ... of several terpenederived polyenynes.
doi:10.1021/acs.orglett.8b00437.s001 fatcat:r37tdr6hnzgsbavx4hhelkd4qy