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Dissecting spatio-temporal protein networks driving human heart development and related disorders
2010
Molecular Systems Biology
Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems-level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting the functional architecture of organ development, we combined detailed phenotype information from deleterious mutations in 255 genes with high-confidence experimental interactome data, and coupled the results to thorough experimental
doi:10.1038/msb.2010.36
pmid:20571530
pmcid:PMC2913399
fatcat:xnf2baglmrbixld6dse4moy4we