A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Rapamycin Inhibits VEGF-Induced Microvascular HyperpermeabilityIn Vivo
2010
Microcirculation
Objective-To test the hypothesis that rapamycin inhibits induced microvascular hyperpermeability directly in vivo. Methods-Male golden Syrian hamsters (80-120g) were treated with either rapamycin (at 0.1, 0.5, 2, and 10 mg/kg i.p.) or vehicle at 24 hours and at one hour prior to preparation of the cheek pouch. Caveolin-1 scaffolding (1 mg/kg; positive inhibitory control) was injected i.p. 24 hours prior to the experiment. 10 −8 M vascular endothelial growth factor (VEGF) or 10 −7 M
doi:10.1111/j.1549-8719.2009.00012.x
pmid:20163539
pmcid:PMC2925471
fatcat:gazbxmm2g5cl3lbvbjuwndukyq