DEVELOPMENT OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF ATAZANAVIR IN TABLET DOSAGE FORM

P Sakpal, S Divekar, B Agarwal, R Khiste
2014 Int. J. Chem. Sci   unpublished
The method is simple, accurate and precise for estimation of Atazanavir in bulk drug by UV-VIS spectrophotometry. The Atazanavir is an anti-HIV drug. Atazanavir is soluble in water, methanol, chloroform, ethanol, acetonitrile, 0.1 N NaOH and 0.1 N HCl. New method has been developed for estimation of Atazanavir in tablet dosage form using 0.1 N HCl. The λ max was found to be 300 nm in 0.1 N HCl. The Beers-Lamberts law was obeyed in the range of 5-30 µ/mL with a regression coefficient 0.992.
more » ... ficient 0.992. Accuracy of proposed method was obtained by recovery studies and the results are obtained on the basis of statistical parameters as per ICH guidelines. The proposed method is found to be accurate, precise, reproducible and economical and it can be employed for routine quality control of Atazanavir in its tablet dosage form.
fatcat:bhc74uuiangupage27o7rvrire