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Effects of antiserum against alpha-rat atrial natriuretic peptide in anesthetized rats
Although synthetic atrial natriuretic peptide is known to increase urinary volume and sodium excretion and to reduce arterial blood pressure, the physiological role of endogenous atrial natriuretic peptide is still unclear. We investigated the effects of specific rabbit antiserum against a-rat atrial natriuretic peptide on hemodynamics, diuresis, and natriuresis in anesthetized rats. A significant rise in mean blood pressure lasted for about 60 minutes after intravenous administration of thedoi:10.1161/01.hyp.10.3.308 pmid:2957323 fatcat:npgvxgrzvbf4rh2mq7xno2nwlq