Synthesis, Characterization and Anti-microbial activity of some Novel Trisubstituted Purine Bearing Amino acid

Manish Jeni, Bhavesh Nathani, K Pandya
A series of Trisubstited purine have been synthesized and tested for in vitro antimicrobial activity on different microorganisms. Synthesis has carried out from 9-benzyl-6-tert-butyl amine-9H-purine-2-amine [2].N-Boc substituted Amino acids reacted with 2 in POCl 3 /Pyridine to give 2, 6, 9-trisubstituted purine 3a-f. Their chemical structures were characterized using IR, 1 H NMR, MASS and elemental analysis. All compounds were tested for antimicrobial activity against S. aureus, S. pyrogenes
more » ... eus, S. pyrogenes E. coli, P. aeruginosa C. albicans, and A. clavatus. These premunary results indicate that some of compounds are exhibiting good activity.