Effect of Azadirachta indica Bio-Compounds against KpsM Protein of Acinetobacter baumannii

V. Thiru Kumaran, A. S. Smiline Girija, P. P. Sankar Ganesh, J. Vijayashree Priyadharshini
2021 Journal of Pharmaceutical Research International  
Acinetobacter baumannii was considered as a low priority pathogen earlier, and is been now reported as a priority pathogen causing nosocomial infections. Selection of natural compounds to target the organism is the need of the hour. Aim: This study is aimed to target the KpsM protein of A. baumannii with the bio-compounds from Azadirachta indica using in-silico docking analysis. Materials and Methods: KpsM protein was retrieved and optimisation of protein was done. After that optimization and
more » ... gand preparation was carried out. It was continued by molinspiration assessment of the molecular properties of selected compounds. It was followed by docking simulation and docking visualisation. Results: Out of the 7 compounds of Azadirachta indica, dihydro diisoeugenol is the best compound to act on the KpsM protein of Acinetobacter baumannii and a binding energy of -6.83Kcal/Mol. Conclusion: The findings of the study reports isoeugenol with more binding energy than other compounds towards the selected protein KpsM of Acinetobacter baumannii. However it requires further experimental studies to understand the mechanism of its actions and safety.
doi:10.9734/jpri/2021/v33i47b33182 fatcat:sh3y4jlgxfb2na5pqzuf7tebri