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Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation
The specification of cartilage requires Sox9, a transcription factor with broad roles for organogenesis outside the skeletal system. How Sox9 gains selective access to cartilage specific cis-regulatory regions during skeletal development had remained unclear. By analyzing chromatin accessibility during the differentiation of neural crest cells into chondrocytes of the zebrafish head, we find that cartilage-associated chromatin accessibility is dynamically established. Cartilage-associateddoi:10.1101/2020.10.15.340703 fatcat:7ochndr4fba2rgv27khkf6xp2u