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Iron overload impairs proliferation of erythroid progenitors cells (BFU-E) from patients with myelodysplastic syndromes
2013
Leukemia research : a Forum for Studies on Leukemia and Normal Hemopoiesis
In patients with myelodysplastic syndromes (MDS) iron overload caused by long-term red blood cell transfusions is an important factor for comorbidity especially in low-risk MDS. In this report we present the results of a comparative study based on colony formation assays of hematopoietic cells in MDS patients with and without iron overload. We demonstrate that iron overload suppresses the proliferation of erythroid progenitors cells (BFU-E), while the myeloid compartment (CFU-GM) was not found
doi:10.1016/j.leukres.2012.11.005
pmid:23259989
fatcat:clr5vduppbadnbmb7gqfkofdza