STUDIES ON URINARY SECRETORY IgA (SIgA)
尿中分泌型IgAに関する研究

Akira Nishio, Yoshiaki Kumamoto
1981 The Japanese Journal of Urology  
We studied urinary SIgA in healthy adult females and patients with various kinds of urinary tract infections and obtained the following results. 1) In healthy adult females, the urinary SIgA levels ranges from 58. 8 to 488. 5ug/dl with a mean of 158. 6ug/dl and SIgA/u-creatinine ratios from 1. 0 to 3. 5 with a mean of 2. 1. Diurnal investigation showed that the excretion increased in the afternoon. 2) In the patients with acute simple cystitis, urinary SIgA excretion obviously increased from
more » ... 8 to 1820. 0ug/dl with a mean of 473. 8ug/dl in urin ry SIgA levels and from 1. 0 to 29. 4 with a mean of 9. 0 in the SIgA/u-creatinine ratios. After the onset of scute simple cysti is, urinary SIgA excretion increased sooner in the patients with recurrent episodes than in those without an episode in the past. The highest excretion was noticed in the patients with a frequency of less than once a year. The excretion returned to normal level immediately after initiation of chemotherapy. 3) In the patients with chronic cystitis, accompanying chronic proliferative changes in the bladder, the urinary SIgA levels ranged from 160. 3 to 942. 0ug/dl with a mean of 381. 7u/dl and the SIgA/ucreatinine ratios from 1. 2 to 9. 7ug/dl with a mean of 5. 2. 4) In the patients with chronic complicated cystitis, the urinary SIgA levels ranged from 382. 5 to 1761. 0ug/dl with a mean of 836. 7ug/dl and the SIgA/u-creatinine ratios from 5. 8 to 26. 0 with a mean of 12. 7. 5) In the patients with urethral syndrome, the urinary SIgA levels ranged from 90. 0 to 742. 0ug/ dl with a mean of 241. 9ug/dl and the SIgA/u-creatinine ratios from 0. 9 to 8. 0 withh a mean of 2. 8. 6) In the patients with acute pyelonephritis, the urinary SIgA levels ranged from 52. 4 to 419. 3ug/ dl with a mean of 219. 3ug/dl and SIgA/u-creatinine ratios from 0. 9 to 5. 1 with a mean of 2. 8. 7) In the patients with chronic pyelonephritis, the urinary SIgA levels ranged from 94. 6 to 316. 8ug/ dl with a mean of 151. 9ug/dl and SIgA/u-creatinine ratios from 0. 7 to 4. 8 with a mean of 2. 5. 8) In the patients with either nephrostomy or ureterostomy, the urinary SIgA levels ranged from 0 to 73. 7ug/dl with a mean of 33. 4ug/dl and SIgA/u-creatinine ratios from 0 to 1. 1 with a mean of 0. 6. In the patients with ileal conduit, the urinary SIgA levels ranged from 27. 3 to 47. 5ug/dl with a mean of 36. 3u/dl and SIgA/u-creatinine ratios from 0. 5 to 1. 1 with a mean of 0. 9. 9) These studies show that urinary SIgA excretion shows an obvious increase in the lower urinary tract infections, while it remains at a low level in the upper urinary tract during infections.
doi:10.5980/jpnjurol1928.72.7_810 fatcat:ytdzv37exndvvb2oi7dry4zhda