Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida

Marina V. Martins, Charles dos S. Estevam, André L. L. M. Santos, Antonio S. Dias, Yolanda K. Cupertino-da-Silva, João X. Araújo-Júnior, Ana Luisa P. Miranda, Eliezer J. Barreiro, Cosimo Pizza, Sonia Piacente, Paola Montoro, Lucindo J. Quintans-Júnior (+3 others)
2012 Revista Brasileira de Farmacognosia  
The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4′-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. In the hot plate test, mice pretreated with 1 showed
more » ... ifi cantly increased reaction times (60-89%). Oral administration of 1 signifi cantly inhibited fi rst and second phases of the formalin-induced pain (50 and 26.5%, respectively), whereas indomethacin inhibited only the second phase of the test (41.2%). Ethanol extract and its fraction showed effects on infl ammatory pain, while neurogenic and infl ammatory pain suppression by 1 is a strong indication of the presence of both central and peripheral effects and suggests its analgesic and anti-infl ammatory potential. Keywords : anti-inflammatory activity antinociceptive activity Maytenus rigida Celastraceae (-)-4'-methylepigallocatechin Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida Marina V. Martins et al. Rev. Bras. Farmacogn. Braz. J. Pharmacogn. 22(3): May/Jun. 2012 599
doi:10.1590/s0102-695x2012005000007 fatcat:4x7m5ltwmbdefjhji5unyogfcq