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Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida
2012
Revista Brasileira de Farmacognosia
The antinociceptive activity of the Maytenus rigida Mart. (Celastraceae) ethanol extract and its ethyl acetate fraction as well as of (-)-4′-methylepigallocatechin (1), a previously isolated compound, was demonstrated in vivo. ED50 for 1 in the writhing test was 14.14 mg/kg. The acetic acid-induced writhing was inhibited by 98.4, 84.4, and 58.3%, respectively, when mice were treated with the ethanol extract, ethyl acetate fraction, and 1. In the hot plate test, mice pretreated with 1 showed
doi:10.1590/s0102-695x2012005000007
fatcat:4x7m5ltwmbdefjhji5unyogfcq