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Phosphorylation of LXRα impacts atherosclerosis regression by modulating monocyte/macrophage trafficking
[article]
2018
bioRxiv
pre-print
LXRα activation in macrophages enhances regression of atherosclerotic plaques in mice by regulating genes crucial for cholesterol efflux, cell motility and inflammation. Diabetes, however, impairs plaque regression in mice. LXRα is phosphorylated at serine 198 (pS198), which affects the expression of genes controlling inflammation, lipid metabolism and cell movement. We hypothesize that LXRα function is affected by hyperglycemia through changes in LXRα pS198. Indeed, macrophages cultured in
doi:10.1101/363366
fatcat:e4d637by5nekdh3bczrlmddzyy