Prostaglandin E2 Signaling: Alternative Target for Glioblastoma?

Jianxiong Jiang, Jiange Qiu, Qianqian Li, Zhi Shi
2017 Trends in Cancer  
Elevated cyclooxygenase-2 (COX-2) and the associated inflammation within the brain contribute to glioblastoma development. However, medical use of COX inhibitors in glioblastoma treatment has been limited due to their well-documented vascular toxicity and inconsistent outcomes from recent human studies. Prostaglandin E2 (PGE 2 ) has emerged as a principal mediator for COX-2 cascade-driven gliomagenesis. Are PGE 2 terminal synthases and receptors feasible therapeutic targets for glioblastoma?
doi:10.1016/j.trecan.2016.12.002 pmid:28718447 pmcid:PMC5518646 fatcat:kmy4hn4tjzg2bp3f44zou62fay