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A selectivity filter at the intracellular end of the acid-sensing ion channel pore
2017
eLife
Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in the channel pore, but experimental verification is lacking due to the sensitivity of this structure to conventional manipulations. Here, we explored the basis for ion selectivity by incorporating unnatural amino acids into the channel, engineering
doi:10.7554/elife.24630
pmid:28498103
pmcid:PMC5449180
fatcat:5msxkzhccrfttjwpkwqqkn2gbe