Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential

Sabine Simon, Steffen Oßwald, Jürgen Roos, Harald Gröger
2012 Zeitschrift für Naturforschung. B, A journal of chemical sciences  
Diethyl malonate turned out to be both a "green" and highly efficient acyl donor in the lipase-catalyzed resolution of amines, thus representing an attractive alternative to currently applied acyl donors. By means of this acyl donor a highly efficient enzymatic process for the resolution of amines, running at high substrate input of up to 200 g/L in an organic solvent classified as "usable" according to the Pfizer Solvent Selection Guide, is presented.
doi:10.5560/znb.2012-0127 fatcat:rndcwt6torcafh7vammw6h646m