We present a novel method of optical tomographic ilnaging and clinical diagnosis that are successfully developed in intense light scattering medium of a living organisrn, using optical tirne domain short,coherence inteference technology. Construction of an interfermeter 、vith a lo、 v coherence light source and a beam scanning yields two-dirnentional reflection tomography with high spatial resolution Of up to 10 μ m. A practical case po、 verfully displayed in clinical diagnosis of ophthalmology

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... s presentedr Optical coherゃ ence tomography(OCT)iS a new diagnostic technology which allo、 vs a cross-seCtiOnal irnage bf the retina, non-invasively in living eyes with fine resolution comparable to histologic section of llght rnicroscopy. Although the fundus can be exarnined at senllhistologic level a bionlicroscope, histopathologic study has been hard to apply it because of rare chance of retinal biopsy or enucleation. OCT revealed the histopathology of macular edema, holes, vitreoretinal interface disease and macular dystrophies ガ % υガ ク ο . OCT proved to be a po、 verfull tool to evaluate the surgical outCOme of macular disorders at histological level. Because OCT ittage is constituted from tissue reflectivity of infrared beam, precaution is required to interpret the croSs-sectional images,