Optical resolution photoacoustic microendoscopy with ultrasound-guided insertion and array system detection

Parsin Hajireza, Tyler Harrison, Alexander Forbrich, Roger Zemp
2013 Journal of Biomedical Optics  
Using a 0.8-mm-diameter image guide fiber bundle consisting of 30,000 single-mode fibers and an external linear array transducer, we demonstrate a dual-mode photoacoustic system capable of ultrasound-guided microendoscope insertion and photoacoustic imaging. The array optical resolution photoacoustic microendoscopy (AOR-PAME) system is designed to visualize the placement of the distal end of an endoscopy probe several centimeters into tissue, transmit scanning focused laser pulses into tissues
more » ... ia the fiber bundle, and acquire the generated photoacoustic signals. A ytterbium-doped fiber laser is tightly focused and is scanned across the proximal tip of the image guide fiber bundle using a two-dimensional galvanometer scanning mirror system. The end of the fiber bundle is used in contact mode with the object. The capabilities of AOR-PAME are demonstrated by imaging carbon fiber networks embedded in tissue-mimicking phantoms and the ears of a 60-g rat. The lateral resolution and signal-tonoise ratio are measured as 9 μm and 40 dB, respectively.
doi:10.1117/1.jbo.18.9.090502 fatcat:5jzycmee7va5jk5pthjqbv3mgi