Histomorphological spectrum of endometrial lesion in women presenting with abnormal uterine bleeding: A 3-year study at a tertiary care center

Dr. Ritu Sharma, T.S. Misra Medical college and Hospital Lucknow, Uttar Pradesh, India, Dr Poornima Mishra, Dr. (Brig.) Nikhilesh Kumar, Dr. Prachi Srivastava, T.S. Misra Medical college and Hospital Lucknow, Uttar Pradesh, India, T.S. Misra Medical college and Hospital Lucknow, Uttar Pradesh, India, T.S. Misra Medical college and Hospital Lucknow, Uttar Pradesh, India
2018 Tropical Journal of Pathology and Microbiology  
Abnormal uterine bleeding (AUB) is the most common presentation amongst the women of all age groups attending the gynecology Out Patient Department. Histopathological evaluation of the endometrial samples plays a significant role in the diagnosis of abnormal uterine bleeding. Aim: To determine the various histomorphological patterns of the endometrium in women presenting with AUB. Material and Method: A retrospective analysis of 183 patients age ranged from 15 to 71 years, presenting with AUB
more » ... esenting with AUB was done who underwent endometrial sampling during a 3-year period from August 2015 to July 2018 in Department of Pathology at T.S Misra Medical College and hospital. Detailed clinical history like age, menstrual status including painful bleeding, heavy menstrual bleeding, periodicity & regularity of cycle were obtained from the case records. Patients were categorized into reproductive age group, perimenopausal and postmenopausal. Specimens were routinely processed and stained with Haematoxylin& Eosin stain and microscopic morphological evaluation was done. Results: The most common age group affected is perimnopausal presenting withAUB frequently seen in 41-50 years of age group (47.5%). The commonest Histomorphological pattern in these patients was proliferative endometrium (38.8%), secretory endometrium (16.3%), endometrial hyperplasia seen in 22 cases (12.0%), hormonal changes/Pill endometrium were seen in 6.0% of the cases and least number cases were of endometrial carcinoma forming 1.1% of the total cases taken in the study. Conclusion: In our study patients with AUB show variable pathology on endometrial biopsy as milder as inflammatory cause to as notorious as malignancy.
doi:10.17511/jopm.2018.i07.08 fatcat:3or3337v4zdobddt4pubryp2dy