In the last two decades Ethiopia has witnessed increasing immigration flows from South Sudan, Somalia and Eritrea. However, these immigrants are not screened for hepatitis B and C which could be additional burden for the local population. Objective: To determine Prevalence of hepatitis B and C viruses, associated risk factors and knowledge, attitude and practice (KAP) among refugees at Pugnido-I refugee camp in Gambela, Ethiopia. Methods: Cross-sectional study was conducted on 453 refugees at

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... gnido-I refugee camp in Gambella region from January to May 2018.Socio-demographic, risk factors and KAP was assessed by using structured questionnaires. Five ml blood sample was collected with serum separator tube. HBsAg and anti-HCV rapid screening tests were performed and those positive samples were confirmed using ELISA method. Data was entered and analyzed using SPSS statistical software version 20. The odds ratio and 95% confidence interval was calculated to assess the strength of the association. P-value less than 0.05 were considered as statistically significant. Results: The overall prevalence of HBV and HCV among refugees was 7.3 %( n=33/453) and 2.0 %( n=9/453) respectively. Of those 6.8% (n=25/370) and 1.4% (n=5/370) of females were positive for HBV and HCV respectively. And 9.6 % (n=8/83) and 4.8 % (n=4/83) of males were positive for HBV and HCV respectively There was no significant association between HBV and proposed risk factors (p>0.05), however, statistical significant association was observed between HCV and age group of 18-25years (AOR=0.045, CI 95%=0.005-0.378, P=0.004) and 26-35years (AOR=0.035, CI 95%0.004-0.301, P=0.002). From the total participants, 86.5%(n= 392/453) did not know how the disease is transmitted, 8.2%(n= 37/453) believed that hepatitis can be transmitted through food, 86.8%(n= 393/453) had no information about the availability of HBV vaccine and 98.5%(n=446/453) were not vaccinated. Conclusion: The prevalence of hepatitis B and hepatitis C among refugees was intermedia [...]