Background. Achatina fulica (A. fulica) snail slime was well known having many advantages especially as moisturizer and antimicrobial, but enzymatic antioxidant properties have not been studied yet. Objective. This study aimed to find the enzymatic antioxidant properties of snail slime extract and to find photoprotective potency in sunburn. Method. This research was an experimental test using randomized post-test only control group design using 75 male BALB/c mice were divided into 15 groups.

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... ere were an untreated group, 4 groups were given various doses of snail slime extract topically, 5 groups were irradiated with UVA 30J/cm2 and 5 groups were irradiated with UVB 200mJ/cm2. Skin biopsy were performed 24 hours after irradiated to be analyzed for enzymatic antioxidants properties of SOD, CAT and GPX, and also histologic changes. Data analysis were conducted with one-way ANOVA and followed by post hoc LSD with SPSS 26. Results. A. fulica snail slime contained enzymatic antioxidant properties of SOD, CAT and GPX respectively 40,59 + 5,79U/mL; 13,73 + 6,13 U/mL and 17,64 + 3,84 mmol/L. These antioxidant properties showed role of photoprotector compared to groups that had been radiated with UVA nor UVB. Topical use of snail slime extract significantly increased the level of SOD, CAT and GPX in sunburn model mice (p<0,05). This study also showed snail slime extract could prevent skin damage caused by UVA nor UVB histologically. Conclusion. Enzymatic antioxidants of A. fulica might have a photoprotector potency.