CLIP-domain serine proteases in Drosophila innate immunity

In-Hwan Jang, Hyuck-Jin Nam, Won-Jae Lee
2008 BMB Reports  
Extracellular proteases play an important role in a wide range of host physiological events, such as food digestion, extracellular matrix degradation, coagulation and immunity. Among the large extracellular protease family, serine proteases that contain a "paper clip"-like domain and are therefore referred to as CLIP-domain serine protease (clip-SP), have been found to be involved in unique biological processes, such as immunity and development. Despite the increasing amount of biochemical
more » ... of biochemical information available regarding the structure and function of clip-SPs, their in vivo physiological significance is not well known due to a lack of genetic studies. Recently, Drosophila has been shown to be a powerful genetic model system for the dissection of biological functions of the clip-SPs at the organism level. Here, the current knowledge regarding Drosophila clip-SPs has been summarized and future research directions to evaluate the role that clip-SPs play in Drosophila immunity are discussed. [BMB reports 2008; 41(2): 102-107]
doi:10.5483/bmbrep.2008.41.2.102 pmid:18315944 fatcat:np5spblbwvfvrpeyycqrcmpwuu