Objective: To study the assessment value of serum 25-hydroxy-vitamin D content detection for patients with diabetic nephropathy. Methods: Healthy subjects, patients with type 2 diabetes mellitus and patients with diabetic nephropathy were selected for study and enrolled in control group, diabetes group and diabetic nephropathy group respectively, and contents of 25-hydroxy-vitamin D, RAS molecules and chemokines in serum as well as contents of podocyte injury molecules in urine were detected.

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... sults: Serum 25-hydroxy-vitamin D content as well as Nephrin, Podocin, CD2AP and α3β1 integrin contents in urine all showed the trend of diabetic nephropathy group < diabetes group < control group, and serum 25-hydroxy-vitamin D content as well as Nephrin, Podocin, CD2AP and α3β1 integrin contents in urine of patients with macroalbuminuria were significantly lower than those of patients with microalbuminuria; contents of PRA, AngII, ALD, MCP-1, FKN, VCAM-1, ICAM-1, OPN and MIF in serum as well as contents of Nesmin in urine all showed the trend of diabetic nephropathy group >diabetes group > control group, and contents of PRA, AngII, ALD, MCP-1, FKN, VCAM-1, ICAM-1, OPN and MIF in serum as well as contents of Nesmin in urine of patients with macroalbuminuria were significantly higher than those of patients with microalbuminuria. Conclusion: Serum 25-hydroxy-vitamin D content significantly decreases in patients with diabetic nephropathy, and it can also assess the activity of RAS system, the degree of inflammatory response and the degree of podocyte injury.