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Abstracts for the 62nd Annual Meeting of the Society for Investigative Dermatology (abstracts 400-599)
Journal of Investigative Dermatology
Six patients received 12 weekly doses of LFA3TIP, a fully human LFA-3/IgG1 fusion protein. 6 mm biopsies were performed at baseline and weeks 7 and 13 (1 week after ®nal dose). Biopsies were snap frozen and analyzed for immunohistochemical markers (CD3, CD4, CD8, and CD2), Ki67, keratin 16, and epidermal thickness. Pan-T cell staining with CD3 demonstrated a decrease in the numbers of epidermal T cells present in 4/6 patients while dermal T cells decreased in 3/6. Staining for CD2 was similardoi:10.1046/j.1523-1747.2001.14323.x fatcat:j7bzjxsifjdkffjlk3e62tjaaa