This clinical prospective study evaluated the clinical and radiographic peri-implant conditions of two unsplinted implants immediate loaded with mandibular overdentures, as well, evaluated the oral health related quality of life (OHRQoL) in these patients. Materials and Methods: Ten totally edentulous patients received 20 implants with ball attachment, being 6 immediate loaded (test group) and 4 conventional loaded (control group). For OHRQoL assessment, the OHIP-EDENT questionnaire was applied

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... before the implants insertion, 3 and 6 months after. After 6 months of implant insertion, the following clinical parameters were evaluated: probing depth, width of the keratinized mucosa, modified bleeding index, modified plaque index. The marginal bone loss was obtained by analyses of periapical radiographs at the day of implant insertion, 3 and 6 months after. Results: There was a significant improvement of quality of life at 3 months in immediate loaded group and at 6 months at the conventional loaded group comparing to initial time (P<0,001) with no significant difference between groups (P=0,488). There was no significant difference between groups for the clinical and radiographic parameters at 6 months. Conclusion: There was no significant difference between groups in all quality of life, clinical and radiographic parameters, however the immediate load provided a better quality of life before the conventional load. Long term studies may be conducted due to follow peri-implant parameters and to obtain implant survival rate.