Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata

Alberto Jorge Oliveira Lopes, Cleydlenne Costa Vasconcelos, Francisco Assis Nascimento Pereira, Rosa Helena Moraes Silva, Pedro Felipe dos Santos Queiroz, Caio Viana Fernandes, João Batista Santos Garcia, Ricardo Martins Ramos, Cláudia Quintino da Rocha, Silvia Tereza de Jesus Rodrigues Moreira Lima, Maria do Socorro de Sousa Cartágenes, Maria Nilce de Sousa Ribeiro
2019 International Journal of Molecular Sciences  
The stingless bee, Melipona fasciculata Smith (Apidae, Meliponini), is a native species from Brazil. Their products have high biotechnological potential, however there are no studies about the biological activities of pollen collected by M. fasciculata. In this context, the present study investigated the chemical composition, anti-oxidant, anti-inflammatory, and analgesic activities of hydroethanolic pollen extracts collected by M. fasciculata in three cities in Maranhão State, Brazil. We
more » ... ed the antioxidant activity of the extracts and inhibitory activity against the cyclooxygenase enzyme using in vitro assays and in allowed to select the extract with higher efficiency to be used on in vivo assays. In these trials, the selected extract showed high anti-inflammatory activity as well as nociceptive effects at central and peripheral level, suggesting that this extract acts on inhibition of histamine release and decreased synthesis of prostaglandins and the in-silico study suggested that polyphenols and acids fatty acids in the extract may be associated with these activities. The results of the present study report the high biological potential of pollen extract and we conclude that the pollen collected by M. fasciculata can be considered as the object of research for new pharmacological alternatives.
doi:10.3390/ijms20184512 fatcat:pedrwshwmjcopixhtmpswirdbq