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An inter-chromosomal transcription hub activates the unfolded protein response in plasma cells
Previous studies have indicated that the transcription signature of antibody-secreting cells is closely associated with the induction of the unfolded protein response pathway (UPR). Here we have used genome-wide and single cell analyses to examine the folding patterns of plasma cell genomes. We found that plasma cells adopt a cartwheel configuration and undergo large-scale changes in chromatin folding at genomic regions associated with a plasma cell specific transcription signature. Duringdoi:10.1101/295915 fatcat:tb3bw7jjbvg7jc7khwcfogaqbq