An inter-chromosomal transcription hub activates the unfolded protein response in plasma cells [article]

Alexandra Bortnick, Zhaoren He, Megan Aubrey, Vivek Chandra, Matthew Denholtz, Kenian Chen, Yin C Lin, Cornelis Murre
2018 bioRxiv   pre-print
Previous studies have indicated that the transcription signature of antibody-secreting cells is closely associated with the induction of the unfolded protein response pathway (UPR). Here we have used genome-wide and single cell analyses to examine the folding patterns of plasma cell genomes. We found that plasma cells adopt a cartwheel configuration and undergo large-scale changes in chromatin folding at genomic regions associated with a plasma cell specific transcription signature. During
more » ... a cell differentiation, Blimp1 assembles into an inter-chromosomal transcription hub with genes associated with the UPR, biosynthesis of the endoplasmic reticulum (ER) as well as a cluster of genes linked with Alzheimer's disease. We suggest that the assembly of the Blimp1-UPR-ER transcription hub permits the coordinate activation of a wide spectrum of genes that collectively establish plasma cell identity.
doi:10.1101/295915 fatcat:tb3bw7jjbvg7jc7khwcfogaqbq