Study of patients attending tertiary care hospital in Guwahati, Assam. profile, histopathological changes in the lacrimal sac and epidemiological characteristics in ch. dacryocystitis. and Methods: 60 clinically est using drops were taken up for the study in a tertiary care hospital in GUWAHATI, Assam from July'07 to June'08. Regurgited materials from lacrimal sac were subjected pathogens. Lacrimal sac samples during daryocystectomy surgery and posterior flaps of lacrimal sac during

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... hinostomy surgery were collected, preserved and sent for histopathological exami cases bacteriological etiology was established in 52 cases (86.67%) while 8 cases (13.33%) were sterile. Among the isolated bacreria, the commonest organism was staphylococcus aureus (28.33%) followed by streptococcus pneumonae (23.33%). Histopathological study showed 100% cases were non suppurative. The commonest type was nonspecific chronic dacryocystitis 22 (36.67%) followed by hyperplastic type 18(30%), fibrotic type 11(1833%) etc. Most of the cases were in the 4th decade of l lower socioeconomic class 47(78.33%). and in 13.33% cases it was sterile culture. Gram positive isolat common organisms (28.33%) followed by streptococcus pneumonae (23.33%) and Gram negative isolates were 26.67% among which Pseudomonas aeruginosa were 10%, E.coli were 10%. Most common change was found chronic dacryocystitis (36.67%).Most of the cases were female (76.66%), housewives (63.33%), belonged to lower socio economic class (78.33%) and in the 4th decade of age(23.33%).