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Abstracts Accepted for Publication
Scientific Abstracts 1071 (IDO1) expression was analysed by Western Blot and expression of enzymes of the kynurenine pathway by real-time PCR. Tryptophan/ kynurenine levels in culture supernatants were quantified by HPLC. Results: SF strongly inhibited the proliferation of co-cultured Th cells. Tryptophan was completely depleted within a few days in co-cultures of SF and Th cells, resulting in eukaryotic initiation factor (eIF)2α phosphorylation, TCRζ-chain downregulation and proliferationdoi:10.1136/annrheumdis-2017-eular.6411 fatcat:g6ukndcscfakfg5e2flq7zcxdq