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Disturbed flow–induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis
2020
JCI Insight
Atherosclerosis develops preferentially in areas of the arterial system, in which blood flow is disturbed. Exposure of endothelial cells to disturbed flow has been shown to induce inflammatory signaling, including NF-κB activation, which leads to the expression of leukocyte adhesion molecules and chemokines. Here, we show that disturbed flow promotes the release of adrenomedullin from endothelial cells, which in turn activates its Gs-coupled receptor calcitonin receptor-like receptor (CALCRL).
doi:10.1172/jci.insight.140485
pmid:33268595
fatcat:ytd3f4jpz5hyfb5znxh2frsb7u