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Along signal paths: an empirical gene set approach exploiting pathway topology
2012
Nucleic Acids Research
Gene set analysis using biological pathways has become a widely used statistical approach for gene expression analysis. A biological pathway can be represented through a graph where genes and their interactions are, respectively, nodes and edges of the graph. From a biological point of view only some portions of a pathway are expected to be altered; however, few methods using pathway topology have been proposed and none of them tries to identify the signal paths, within a pathway, mostly
doi:10.1093/nar/gks866
pmid:23002139
pmcid:PMC3592432
fatcat:pq2ot5fjlzg7jli6yhlc4lv634