Primary prophylaxis with ciprofloxacin in cirrhotic patients with ascites: a randomized, double blind study

Félix Téllez-Ávila, José Sifuentes-Osornio, Varenka Barbero-Becerra, Ada Franco-Guzmán, Roberto Ruiz-Cordero, Roberto Alfaro-Lara, Angeles Hernández-Ramírez, Florencia Vargas-Vorácková
Annals of Hepatology  
INTRODUCTION AND AIM. There is scarce information about primary prophylaxis in cirrhotic patients. The aim was to assess the efficacy of ciprofloxacin for primary prophylaxis for bacterial infections in patients with cirrhosis of the liver and ascites. MATERIAL AND METHODS. A randomized, double-blind placebo-controlled clinical trial was conducted. Patients were randomized to receive oral ciprofloxacin 500 mg/day or placebo for one month. A basal evaluation and repeated assessments at 4, 6, 12,
more » ... 18, and 24 weeks afterwards, or whenever a primary endpoint occurred were done.
pmid:24378268 fatcat:jkgc2xdm3baxfo2eyaigvz7kgu