Chemical Constituents from Cultures of the FungusMarasmiellus ramealis(Bull.) Singer

Ningning Yang, Qingyun Ma, Shengzhuo Huang, Haofu Dai, Zhikai Guo, Xuehua Lu, Yuguang Wang, Zhifang Yu, Youxing Zhao
2014 Journal of the Brazilian Chemical Society  
A investigação química das culturas do fungo Marasmiellus ramealis resultou na primeira isolação de onze compostos incluindo dois novos sesquiterpenoides do tipo eudesmano 14(10→1)abeo-eudesmano-13-hidroxil-11-eno, 14(10→1)abeo-eudesmano-11,13-diol, e o novo derivado de meleína (R)-(-)-5-etoxicarbonil meleína. A atividade inibitória da aceticolinesterase (AChE) dos dois primeiros compostos foi avaliada, que mostraram ser ativos com uma porcentagem de inibição de 29 e 41%, respectivamente, em
more » ... pectivamente, em uma concentração de 100 µmol L -1 . Chemical investigation on the cultures of the fungus Marasmiellus ramealis resulted in the first isolation of eleven compounds including two new eudesmane-type sesquiterpenoids 14(10→1)abeo-eudesmane-13-hydroxyl-11-ene, 14(10→1)abeo-eudesmane-11,13-diol, and the new mellein derivative (R)-(-)-5-ethoxycarbonyl mellein. The first two compounds were evaluated for their inhibitory activity against acetylcholinesterase (AChE), and proved to be active with a percentage inhibition of 29 and 41%, respectively, at a concentration of 100 µmol L -1 .
doi:10.5935/0103-5053.20140206 fatcat:2shmpee3pvc6zju3q3urtuq7wy