EXPERIMENTAL STUDIES ON ALLERGIC LABYRINTHITIS

T. OIKAWA
1959 Nippon Jibiinkoka Gakkai Kaiho  
Hearingloss due to allergic labyrinthitis was measured experimentally. 0.5cc of 2% egg white albumin solution was injected subcutaneously into the abdominal wall of guinea pigs every 4 days. These injections were repeated until the abdominal wall showed Arthus phenomenon. 0.2cc of 5% albumin solution was injected through the tympanic membrane of the animals into the middle ear cavity, when the animals were expected to show maximal allergy i.e. about 7 days after the appearance of IV degree of
more » ... e of IV degree of Arthus phenomenon. Marked allergic inflammation was histologically observed in the cochlea as well as in the middle ear 4 and 24 hours following the tympanal injection. Cochlear microphonics were measured by Tasaki's method in the animals treated as above mentioned. Allergic inflammation of the cochlea decreased the microphonics in a range of frequencies higher than 2000cycles. Individual variation of from almost normal to marked decreased level of the microphonics was observed.
doi:10.3950/jibiinkoka.62.2410 fatcat:3knts2j3crdsrhvmavrjfv3kly