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Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons
Journal of Neuroscience
Neuronal apoptosis plays a critical role in both normal development and disease. However, the precise molecular events controlling neuronal apoptosis are not well understood. Previously, we hypothesized that cell cycle regulatory molecules function in controlling the apoptotic pathways of trophic factordeprived neurons. To test this hypothesis, we used the RNA alphavirus Sindbis to express three known cyclin dependent kinase inhibitors (CKIs), p16 ink4 , p21 waf/cip , and p27 kip1 , anddoi:10.1523/jneurosci.17-23-08975.1997 pmid:9364045 fatcat:w3yjiow6wfenvdu7lo6r3s2mom