A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf
.
Incorporation of an Internal Ribosome Entry Site-Dependent Mechanism in Arsenic-Induced GADD45 Expression
2007
Cancer Research
We have previously shown that trivalent arsenic (arsenite, As 3+ ) is able to induce GADD45A expression in human bronchial epithelial cells through activation of c-Jun NH 2terminal kinase and nucleolin-dependent mRNA stabilization. In the present report, we show that As 3+ is capable of inducing translation of the GADD45A protein through a cap-independent, or rather, an internal ribosome entry site (IRES)dependent mechanism. In growth-arrested cells, As 3+ elevated the GADD45A protein level in
doi:10.1158/0008-5472.can-07-0867
pmid:17616671
fatcat:qu2ln65b7zbd7js37i3g2zubaa