In this paper, we study the existence and uniqueness of positive solutions to a class of multipoint boundary value problems for singular fractional differential equations with the p-Laplacian operator. Here, the nonlinear source term f permits singularity with respect to its time variable t. Some fixed-point theorems such as the Leray-Schauder nonlinear alternative, the Schauder fixed-point theorem, and the Banach contraction mapping principle and the properties of the Gauss hypergeometric

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... ion are used to prove our main results. And by employing the upper and lower solutions technique, we derive a new approach to obtain the maximal and minimal solutions to the given problem. Finally, we present some examples to demonstrate our existence and uniqueness results.