This paper proposes concept of bipolar neutrosophic refined set and its some operations. Firstly, a score certainty and accuracy function to compare the bipolar neutrosophic refined information is defined. Secondly, to aggregate the bipolar neutrosophic refined information, a bipolar neutrosophic refined weighted average operator and a bipolar neutrosophic refined weighted geometric operator is developed. Thirdly, to select the most desirable one(s) in a decision making problem, based on

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... rs and the score, certainty and accuracy functions, a bipolar neutrosophic refined multiple criteria decision-making approach, in which the evaluation values of alternatives on the attributes take the form of bipolar neutrosophic refined numbers, is proposed. Finally, an algorithm is introduced and a numerical example is employed to illustrate the effectiveness and feasibility of this method in medical diagnosis.