Simulating genetic networks made easy: network construction with simple building blocks

S. Vercruysse, M. Kuiper
2004 Bioinformatics  
We present SIM-plex, a genetic network simulator with a very intuitive interface in which a user can easily specify interactions as simple 'if-then' statements. The simulator is based on the mathematical model of Piecewise Linear Differential Equations (PLDEs). With PLDEs, genetic interactions are approximated as acting in a switch-like manner. Availability: The Java program, examples and a tutorial are available at
doi:10.1093/bioinformatics/bth478 pmid:15319258 fatcat:2o7vypcqinav7if4trcr2hhzky